Associate Principal Scientist Cell Immunology

Job title:

Associate Principal Scientist Cell Immunology

Company

AstraZeneca

Job description

Associate Principal Scientist Cell ImmunologyLocation: Cambridge, UKCompetitive salary & BenefitsWorking at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a high calibre Associate Principal Scientist to join the Cell Immunology team, within the Cell, Gene and RNA Therapies department of Discovery Sciences. The position is placed at AstraZeneca’s Global HQ R&D site in Cambridge, UK.What you’ll do:We have an opening for an Associate Principal Scientist, who will be responsible for driving the science and strategic direction of our immune cell engineering platform to improve how we manufacture immune cell therapies.This lab-based role will be focused on developing novel high capacity viral vector technologies to enable AZ’s portfolio of cell therapies to advance to the Clinic, and will involve working as part of a multi-disciplinary team delivering strategic directions in key scientific areasRole Profile:Individual contributor accountable for the development of scientific research strategies related to viral vector development and gene delivery methods for the creation of gene edited immune therapies to support Oncology Cell Therapy. Sets strategic direction to ensure that the scientific priorities are aligned to business need and act as the internal expert in this field.Role model for excellence in execution of experiments in the laboratory and delivery of data to projects.A scientific leader, with a track record of successful delivery of innovation to projects and a large external networkInitiates and manages internal and external research investigations, collaborations, and partnerships in line with agreed business needs to exploit new technologies or external services and ensure their adoption within AstraZeneca and uses technical expertise and applies specialist knowledge to lead groundbreaking platform developments in line with business needs.Keeps abreast of trends within the external scientific and technological world to transform novel ideas appropriately into platform activities and project impact within AstraZeneca.Shares experience, knowledge, and industry developments with peer scientists in AstraZeneca, other internal concerned parties, or external organisations with the purpose of growing their general level of competence and industry awareness.Manages key partners and collaborators to oversee delivery and understand future needsEncouraged to hold significant matrix roles, contributing to the wider organisationPlays a key role in the scientific development of staff, ensuring that the capability maintains a leading presence and keeps pace with the needs of the businessResponsible for determining which processes and methodologies should be pursued and making decisions about how much resources to invest in them or contributes to this decision-making process as a valued expert.Ensures own work, and the work of others, is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards.Essential for the rolePh.D. in virology, immunology, cell biology or molecular biology plus at least 3 years of academic or industrial research experience or BSc/MSc degree with 6+ years within the pharmaceutical industry or equivalent experience in academia.Experience with viral vector engineering, state-of the-art cloning methods, cassette optimisation, and multi-gene expression construct developmentExpert in viral packaging and manufacturing including Adenovirus, Adeno-Associated virus, and LentivirusExperience with mammalian cell culture (stable and adherent lines), genetic engineering (e.g. CRISPR), and molecular and cell biology techniques such PCR and RT-PCR, FACS, flow cytometry, FACS, transfection, transduction, and assay development.Experience of working in external collaborations both in academia and pharmaceutical industryTrack record in scientific excellence as demonstrated by prior project/technology development success and publication history.Experience with mentoring, supervising, coaching junior staff.Desirable for the roleDeep expertise in primary cell culture and manipulation, in particular primary immune cells e.g. T cells.Knowledge of drug discovery and drug discovery-related subject areasExpert in gene editing technologies.Experience in crafting and/or working with sophisticated immunoassays including advanced flow cytometry, multiplexed cytokine assays, cytotoxicity assays.Practical understanding of cell and gene therapy landscape including discovery, development, and manufacture.So, what’s next?Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!To be considered for this exciting opportunity, please complete the full application at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.Welcome with your application no later than 19/07/2024Where can I find out more?Follow AstraZeneca on LinkedInOn FacebookFollow us on InstagramWe will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform crucial job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.Date Posted 05-Jul-2024Closing Date 19-Jul-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

Expected salary

Location

Cambridge

Job date

Sun, 07 Jul 2024 02:47:07 GMT

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