Internal Applicants Only – Research Associate (stem cell models)

Job title:

Internal Applicants Only – Research Associate (stem cell models)

Company

Cardiff University

Job description

School / DirectorateSchool of MedicineAdvertThis post is currently open to employees of Cardiff University only. Please do not apply if you do not have a current contract of employment with the University.Internal Applicants Only – Research Associate (Stem Cells)
Division of Psychological Medicine and Clinical Neuroscience
School of Medicine
College of Biomedical and Life SciencesUK Dementia Research Institute at Cardiff University is one of six new Dementia Research Institute UK centres. The UK DRI is a new well-funded institute focused on elucidating and targeting the pathways and mechanisms underlying neurodegenerative disease. We are seeking applications from highly motivated individuals for a post-doctoral position working with the group of Prof Caleb Webber at the Dementia Research Centre in Cardiff University. The role will be focussed on the use of iPSC models of dopaminergic neurons and other cell types to understand the metabolic dysfunction and genetic influences towards Parkinson’s Disease. You will work in a multidisciplinary environment with opportunities to grow your science. Beyond this, the UK DRI provides a premier research network across the UK and provides excellent opportunities specifically for early career researchers (ECR), including scientific meetings, training opportunities and ECR-focussed funding calls.You should have a PhD degree in neuroscience (or nearly completion), stem cell research or equivalent experience. Experience in human pluripotent stem cell culture, neuronal differentiation techniques and cellular phenotyping would be highly advantageous, as would experience in cellular imaging techniques such as qPCR, confocal microscopy , Western Blotting and Immunocytochemistry, immunohistochemistry and/or RNA sequencing preparation.We are looking for an enthusiastic individual with a proactive and flexible attitude to work, and an interest in learning new concepts and technologies. The Centre provides an excellent research environment in an international and interactive atmosphere.This post is based at the Hadyn Ellis Building, Cathays campus.
For informal enquiries please contact Caleb Webber (WebberC4@cardiff.ac.uk)This post is full-time (35 hours per week), available from 01.01.2025 and fixed term until 30.11.2027.Salary: £40,247 – £45,163 per annum (Grade 6). Appointments to roles at Cardiff University are usually made at bottom of scale unless in exceptional circumstances.The majority of roles at Cardiff University are currently operating under “blended working” arrangements, with staff having the flexibility to work partly from home and partly from the University campus depending on specific business requirements. Discussions around these arrangements can take place after the successful candidate has been appointed.Cardiff University offers many excellent benefits, including 45 days annual leave (incl bank holidays), local pension scheme, a cycle to work scheme and other travel initiatives, annual increments within the pay scale, and more. It is an exciting and vibrant place to work, with many different challenges and is a proud Living Wage supporter.How we will support you in performing in this role –There are some things that you must have before you can start this role (see ‘Essential Criteria’), but other things can be developed either through training, or just by general on-the-job experience. We want to support and develop you once you have started in the role using a combination of the following to get the best out of you:1. Regular one-to-ones with your manager
2. An experienced and supportive team around you
3. Supporting you through job-relevant training and development that you may require
4. A mentoring schemeClosing date: Friday, 20 December 2024External applications are currently not being considered for this post. If the decision is made to open the post to external candidates, the strapline at the top will be removed and you will be given ample time to apply – please check back periodically for details.Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds. We therefore welcome applicants from all sections of the community regardless of sex, ethnicity, disability, sexual orientation, trans identity, relationship status, religion or belief, caring responsibilities, or age. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.Cardiff University is a signatory to the San Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions we will evaluate applicants on the quality of their research, not publication metrics or the identity of the journal in which the research is published. More information is available at:Applications may be submitted in Welsh, and an application submitted in Welsh will not be treated less favourably than an application submitted in English.Post Reference Number19347BRJob DescriptionJob Purpose
To conduct research for a Moondance Foundation funded project to explore cellular dysfunction underlying Parkinson’s disease using iPSC models and contribute to the overall research performance of the School and University, carrying out high impact research resulting in high-quality publications in international journals. To pursue excellence in research and to inspire others to do the same.Key DutiesResearch

• To conduct research to elucidate metabolic dysfunction in Parkinson’s disease using iPSC models
• To contribute to the overall research performance of the School and University by the production of measurable outputs including bidding for funding, publishing in national academic journals and conferences, and the recruitment and supervision of postgraduate research students.
• To develop research objectives and proposals for own or joint research including research funding proposals
• To undertake administrative tasks associated with the research project, including the organisation of project meetings and documentation and the implementation of procedures required to ensure accurate and timely reporting.
• To prepare research ethics and research governance applications as appropriate and ensure compliance with legal and regulatory requirements in respect of equality and diversity, data protection, copyright and licensing, security, financial and other University policies, procedures and codes as appropriate.
• To review and synthesise existing research literature within the field and continually update knowledge and understanding in the field or specialism and translate knowledge of advances in the subject area into research activity.
• To participate in School research activities.
• To build and create networks both internally and externally to the university, to influence decisions, explore future research requirements, and share research ideas for the benefit of research projects

Role Specific Duties

• To prepare reports for external funding bodies, internal research committees and meetings as appropriate.
• To analyse and interpret the results of the research drawing conclusions on the outcomes.
• To suggest and contribute to the development of research techniques and methods in collaboration with colleagues.
• To assist in the supervision of student projects and the development of student research and assessment.
• To plan and perform research within an established programme, this includes laboratory experimentation, critical evaluation and interpretation, data and statistical analysis and data recording.

Other

• To engage effectively with industrial, commercial and public sector organisations, professional institutions, other academic institutions etc., regionally and nationally to raise awareness of the School’s profile, to cultivate strategically valuable alliances, and to pursue opportunities for collaboration across a range of activities. These activities are expected to contribute to the School and the enhancement of its regional and national profile.
• To undergo personal and professional development that is appropriate to and which will enhance performance.
• To participate in School administration and activities to promote the School and its work to the wider University and the outside world.
• Any other duties not included above, but consistent with the role.

Salary Range Max.45,163GradeGrade 6Salary Range Min.40,247Job CategoryAcademic – Research, Medical & DentalAdditional InformationIMPORTANT: Evidencing Criteria
Candidates should evidence that they meet ALL of the essential criteria as well as, where relevant, the desirable criteria.As part of the application process, you will be asked to provide this evidence via a supporting statement. Please ensure when submitting this document / attaching it to you application profile you name it with the vacancy reference number, in this instance, 19347BRCareer PathwayResearchPerson SpecificationEssential CriteriaQualifications and Education
1. Postgraduate degree at PhD level (or nearing completion / submission) in neuroscience, stem cell research or relevant industrial experienceKnowledge, Skills and Experience
2. An established expertise and proven portfolio of research and/or relevant industrial experience within the following research fields:

• Human pluripotent stem cell culture
• Neuronal differentiation
• Cellular phenotyping. 3. Knowledge of current status of research in research in pluripotent stem cells, metabolic disorders and neurodegenerative diseases.

4. Proven ability to publish in national and international recognised scientific journals
5. Proven ability to be successful in competitive research fundingCommunication and Team Working
6. Proven ability in effective and persuasive communication
7. Ability to supervise the work of others to focus team efforts and motivate individuals and participate in one-on-one and group meetings periodically to stay up-to-date with laboratory and scientific records.Other
8. Proven ability to demonstrate creativity, innovation and team-working within work
9. Proven ability to work without close supervision and to plan and execute research independently.Desirable Criteria10. Experience in CRISPR genome editing of mammalian cells and/or using gene expression modulating tools such as shRNA.
11. Extensive experience in the use of imaging programmes such as Photoshop, image J, Cell Profiler etc.
12. Experience in molecular biology and signal transduction pathway analysis
13. Experience in RNA handling, preparation and RNA-seq.
14. Experience in drug screening analysis and high-throughput imaging.

Expected salary

£40247 – 45163 per year

Location

United Kingdom

Job date

Sun, 15 Dec 2024 00:39:04 GMT

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