PhD in physical-chemistry (M/F): enzymatic treatment of biofilms

Job title:

PhD in physical-chemistry (M/F): enzymatic treatment of biofilms

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Job description

Offer DescriptionThis thesis is part of a major interdisciplinary project at the interface between soft matter physics, physical chemistry and biochemistry, involving various partners from Strasbourg, Paris and Le Mans. Based at the Institut Charles Sadron in Strasbourg, the project will involve regular exchanges with the other partners. The PhD student will be hosted in the ICS PECMAT team, in close interaction with PhD students/researchers and engineers from other research teams (PECMAT, M3, TSP) and platforms (InCa, Plamics, Carmac).The World Health Organization continues to alert the health sector to the emergence and proliferation of multi-resistant microbial strains to antibiotics. Bacterial resistance results in biofilm which are difficult to treat. In Europe, one in twenty patients will contract a nosocomial infection during their hospitalization, representing the sixth leading cause of death in hospitals. Specific treatment of mature biofilm is needed for wound treatment or for water distribution systems. The aim of the PhD project is to develop enzymatic solutions to treat bacterial biofilms. The project will be part of a larger interdisciplinary project at the interface of soft matter physics and biochemistry. More detailed information will be provided at a more advanced stage of the hiring process.Activities:
– Preparation of aqueous solutions of water-soluble enzymes and polymers
– Characterize the activity of enzymes in different environments
– Characterize the secondary structure of enzymes by infrared spectroscopy and circular dichroism
– Develop a model biofilm using natural polymers and characterize them by confocal microscopy
– Characterization of the antibacterial properties of the developed solutions in microbiology
– Interpretation and exploitation of the results, presentation in English on oral or written formsSkills:
The candidate has to hold a Master degree in physical chemistry of physics in soft matter science and have the following skills:
– Good knowledge of the physical chemistry of polymers or proteins in aqueous solution
– Ease in the scientific communication of results
– Sense of organization and teamwork
– Capacity and desire to be involved in interdisciplinary scientific activities
– English level B1 minimumWhere to apply WebsiteRequirementsResearch Field Chemistry Education Level Master Degree or equivalentResearch Field Physics Education Level Master Degree or equivalentResearch Field Physics Education Level Master Degree or equivalentLanguages FRENCH Level BasicResearch Field Chemistry » Physical chemistry Years of Research Experience NoneResearch Field Physics » Chemical physics Years of Research Experience NoneResearch Field Physics » Biophysics Years of Research Experience NoneAdditional InformationWebsite for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institut Charles Sadron Country France City STRASBOURG GeofieldContact CitySTRASBOURG WebsiteSTATUS: EXPIREDShare this page

Expected salary

Location

Strasbourg, Bas-Rhin

Job date

Thu, 29 Aug 2024 23:32:39 GMT

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