Protein Purification Scientist

Job title:

Protein Purification Scientist

Company

GlaxoSmithKline

Job description

Biopharm Process Research, R&D Stevenage, is looking for an enthusiastic and passionate scientist, to join a high performing team developing purification processes to support the progression of GSK’s innovative early stage Biopharm portfolio.This person will have the opportunity to work with state-of-the-art purification hardware and robotic liquid handling systems, cutting edge analytics and execute the latest process development approaches.This pivotal lab-based role sits within GSK’s wider Biopharm Process Research (BPR) group, which straddles drug discovery and product development. Scientists can expect to deal with a range of different biomolecules, from monoclonal antibodies (mAbs) to more challenging modalities such as bispecific antibodies, ADCs, oligonucleotides and recombinant proteins.We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpageIn this role you will

• Rapidly develop and optimise robust downstream purification processes which can be scaled up to supply material for early-stage clinical trials (Phase I & II).
• Support the development of toxicology material manufacturing capability in house.
• Perform necessary work packages to characterise purification process performance and where necessary, highlight and discharge biomanufacturing risks.
• Produce the reference batches of material to support analytical development and preclinical studies.
• Author detailed technical reports and process transfer documents to support tech transfer activities.
• Use high-throughput automation techniques in process development.

Why you?Basic Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:

• MSc or Bachelor’s degree in Biology, Biochemistry, Biotechnology, Biochemical Engineering or related discipline.
• Background in Protein Sciences and/or Biomanufacturing.
• Practical understanding of common downstream processing unit operations and Bioprocess development (with a focus at the early stage).
• Experience of working on complex research projects both as an individual and as part of a team.

Preferred Qualifications & Skills:Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• PhD in related discipline and/or relevant industrial experience.
• Experience in running AKTA platforms such as AKTA Avant, AKTA Explorer and AKTA Pilot.
• Experience of working with a range of molecule formats such as bispecific, recombinant proteins, fc-fusions and a deep understanding of the link to process.
• Understanding of upstream processing operations and common challenges; understanding of process analytical technologies and/or upstream/cell culture concepts.
• Experience of process transfer, particularly in the early clinical space.
• Understanding of statistical design of experiments, and common data analysis and visualisation techniques.

Closing Date for Applications – 05 Aug 2024 (COB)Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. 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Expected salary

Location

Stevenage, Hertfordshire

Job date

Wed, 24 Jul 2024 03:06:12 GMT

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