Senior Scientist – Chemical Biology

Job title:

Senior Scientist – Chemical Biology

Company

GlaxoSmithKline

Job description

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpageSenior Scientist – Chemical BiologyThis is an opportunity for a Chemist/Chemical Biologist who has a passion for identifying and validating targets from disease-relevant phenotypic screens.You will collaborate with experts across multiple disciplines including genomic sciences, computational chemistry and biology and medicinal chemistry. Additionally, there will be onward training in chemical biology available to you to develop your skills and progress.We require this role to be based at Stevenage only.Job PurposeGSK’s Chemical Biology department supports the delivery of our early-stage pipeline of innovative medicines which is built on GSK’s strategic investment in human genetics and functional genomics.Working in partnership with GSK’s Research Units, our team of chemical biologists is accountable for the design and application of well annotated compound libraries for novel target identification and validation in disease-relevant screens. The department is increasingly interdisciplinary, integrating technical expertise in synthetic and medicinal chemistry, molecular cell biology, and biochemistry. To deliver on our growing portfolio, we are expanding to add technical capabilities which will aid the discovery of tractable targets and guide optimal choice of modality.In this role you will…

• Implement strategies for selection and design of high-quality chemical probes for cellular phenotypic screening and develop strategies for target deconvolution, working directly in support of GSK’s expanding early-stage discovery pipeline.
• Be integral to our efforts to identify tractable therapeutic targets from cellular phenotypic screens, through the application of chemistry and molecular pharmacology skills.
• Influence the scientific and experimental strategies of the team and contribute to a culture and environment of scientific excellence.
• Work in a collaborative manner on complex biological systems with scientists in other line functions, particularly the Research Units and Genomic Sciences.

Why you?Basic QualificationsWe are looking for professionals with these required skills to achieve our goals:

• First or upper second-class honours degree in chemistry, medicinal chemistry, chemical biology or a related field.
• PhD/DPhil, or significant research experience, in the field of chemical biology / medicinal chemistry / molecular pharmacology or a related field. Candidates with some post-doctoral experience are also encouraged to apply.
• Knowledge of, and strong interest in, phenotypic screening, design principles for chemogenomic libraries and strategies to validate hits from phenotypic screens.
• Experience in the design, synthesis, selection and application of chemical probes to study biological systems.
• Understanding and appreciation of cell biology / molecular biology techniques which can be used to characterise novel chemical tools for drug target identification and validation.
• A strong track record of high personal productivity working at the chemical biology / cell biology interface.

Preferred QualificationsIf you have some of the following characteristics, it would be a plus:

• Knowledge or experience in molecular pharmacology.
• Knowledge or experience of collecting, integrating, mining and analysing complex biological data to build testable hypotheses.
• Coding experience (e.g. R, Python and/or SQL) for data analysis.
• Interest and/or some experience in the application of computational methods to study pathways and identify targets.
• Successful, collaborative experiences of working in integrated, multidisciplinary teams of e.g. chemists, cell biologists, biochemists, chemoproteomics scientists and computational biologists.

Closing Date for Applications: Monday 8th July 2024Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receive .As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.

Expected salary

Location

Stevenage, Hertfordshire

Job date

Wed, 26 Jun 2024 05:57:02 GMT

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